USP Simulated Gastric Fluid TS (SGF, pH 1.2) BZ574
Product Code: BZ574
Manufacturer: Biochemazone
Available Pack Sizes: 100 mL, 200 mL, 500 mL, 1 L (with pepsin or without enzyme)
Custom Bulk Quantities Available
Product Overview
Biochemazone USP Simulated Gastric Fluid TS BZ574 is prepared to the United States Pharmacopeia test solution “Gastric Fluid, Simulated, TS”: sodium chloride and hydrochloric acid with purified pepsin, at a pH of about 1.2. It is the compendial medium for dissolution, disintegration and drug-release tests that call for simulated gastric fluid.
Two versions are offered. With pepsin follows the full USP TS composition (per litre: 2.0 g sodium chloride, 3.2 g pepsin and 7.0 mL hydrochloric acid). Without enzyme is the same acid–salt solution with the pepsin left out, for methods that specify simulated gastric fluid without enzyme and for acid-stage testing.
Each batch is prepared with ISO 3696 compliant high-purity water under Biochemazone’s ISO 9001 / GMP quality system and checked for pH before release. For a pH 1.5 medium see our existing Simulated Gastric Fluid BZ175.
Key Features & Benefits
✅ Prepared to USP TS – Composition of “Gastric Fluid, Simulated, TS”
✅ pH About 1.2 – Checked on every batch
✅ Two Versions – With pepsin (full TS) or without enzyme
✅ Flexible Storage – 2–30 °C for short-term use; enzyme version best kept at 2–8 °C
✅ ISO 3696 Grade Water – Prepared using high-purity laboratory water
✅ Ready-to-Use – No weighing, acid handling or pH adjustment
✅ Consistent Batch-to-Batch – Reproducible medium for QC release testing
✅ Made in Canada – Manufactured under ISO 9001 / GMP quality systems
Applications
🧪 Compendial Dissolution & Disintegration
• Dissolution testing of tablets and capsules in SGF
• Disintegration tests that specify simulated gastric fluid
• Gelatin-capsule cross-linking investigations (with pepsin)
💊 Formulation Development
• Acid-stage testing of enteric-coated and delayed-release products
• Acid stability and degradation studies of drug substances
• Gastric-resistance screening of coatings and capsules
🔬 Research
• Protein digestibility and pepsin-resistance assays
• Supplement, probiotic and nutraceutical acid-survival studies
• Medical-device and material exposure to gastric conditions
Usage Areas
- Pharmaceutical quality-control laboratories
- Formulation and analytical development laboratories
- Contract testing and research organisations
- Nutraceutical and supplement manufacturers
- Universities and food-safety laboratories
Typical Properties
- Appearance: Clear, colourless to faintly yellow liquid
- pH: about 1.2
- Composition (with pepsin), per litre: 2.0 g sodium chloride, 3.2 g pepsin, 7.0 mL hydrochloric acid
- Composition (without enzyme): sodium chloride and hydrochloric acid only
- Water Grade: ISO 3696 purified water
- Hazard: Acidic solution – handle with gloves and eye protection
Storage & Stability
- Storage Temperature: 2–30 °C
- Shelf Life: 1 year for unopened bottles
- Shipping: Room temperature
- Enzyme version (with pepsin): best kept at 2–8 °C for prolonged storage and enzyme activity; storage at 2–30 °C is fine for short-term use
- Mix gently before use
Customization Options
- pH adjustment (for example pH 1.5, 2.0 or 3.0)
- Pepsin activity or concentration to customer specification
- Sterile-filtered version
- Custom pack sizes and bulk / OEM supply
Ordering Information
BZ574 is available in standard laboratory sizes or OEM/bulk supply formats.
📄 MSDS, Technical Datasheet, and Certificate of Analysis (CoA) available upon request
📧 Email: info@biochemazone.com
🌐 Website: www.biochemazone.com
⚠️ For laboratory research and in vitro testing only. Not for human or animal use.
