Protein-Free Plasma Substitute – Synthetic Plasma without Proteins, pH 7.4 BZ437
Product Code: BZ437
Manufacturer: Biochemazone
Available Pack Sizes: 100 mL, 200 mL, 500 mL, 1 L
Custom Bulk Quantities Available
Product Overview
Biochemazone Protein-Free Plasma Substitute BZ437 is a sterile, ready-to-use synthetic fluid at pH 7.35 to 7.45 designed to mimic the osmotic and electrolyte properties of human plasma, without proteins or amino acids. Its osmolality is 290 to 310 mOsm/kg, and it is sterilized by filtration.
It is made for applications in which a protein-free environment is essential: testing the biocompatibility and performance of medical devices without interference from protein, biochemical assays that proteins would complicate, and in vitro research in which proteins could alter the outcome. It is also used in drug development and toxicology studies.
It is supplied stabilized, with an azide-free preservative that is both bacteriostatic and bactericidal, and has a 1-year shelf life unopened; a preservative-free version (6-month shelf life) and a dried Powder Version Kit are available on request. The pH can be supplied from 6.8 to 9.2. This simulated fluid is for scientific research and in vitro use only; it is not for clinical diagnosis or treatment. For the plasma simulant with proteins and amino acids see Artificial Plasma Fluid (BZ273); for the protein-free serum equivalent see Protein-Free Serum Substitute (BZ438).
Key Features & Benefits
✅ Protein-Free – No proteins or amino acids; less interference in the experiment
✅ Osmotic and Electrolyte Balance – Mirrors human plasma; osmolality 290–310 mOsm/kg
✅ pH 7.35–7.45 – Available from pH 6.8 to 9.2
✅ Stabilized, Azide-Free – Bacteriostatic and bactericidal preservative; 1-year shelf life unopened. Preservative-free version on request
✅ Sterile-Filtered & Ready to Use – No weighing, mixing or pH adjustment before the test
✅ Reproducible & Standardized – Consistent batch-to-batch composition for routine QC and inter-laboratory comparison
✅ Made in Canada – Manufactured under ISO 9001 / GMP quality systems
Applications
🩺 Medical Device Testing
• Biocompatibility and performance of devices
• Testing without interference from protein
🧪 Biochemical Assays
• Assays that need a protein-free environment
• Avoiding the complications proteins introduce
🔬 In Vitro Research
• Studies in which proteins could alter the outcome
• Drug development
• Toxicology studies
Typical Properties
- Appearance: Clear solution
- pH: 7.35 to 7.45 (available from 6.8 to 9.2)
- Osmolality: 290–310 mOsm/kg
- Composition: Electrolyte solution without proteins or amino acids
- Preservative: Azide-free, bacteriostatic and bactericidal; preservative-free version on request
- Format: Sterile-filtered, ready-to-use liquid, stabilized
Storage, Shelf Life & Transportation
- Storage Temperature: 2–30 °C, protected from light
- Transportation: At room temperature
- Shelf Life: 1 year (unopened)
- Preservative-Free Version: Available on request – shelf life 6 months unopened at 2–30 °C
- Powder Version Kit: Available on request – 2-year shelf life, easy to reconstitute and suitable for culture-related applications; recommended when a preservative is not required
- After Opening: Handle aseptically; close tightly after use and do not return unused material to the container
Customization Options
Customization available on request:
- pH from 6.8 to 9.2
- Contents to your specification
- Preservative-free (not-stabilized) version
- Powder Version Kit, custom pack sizes and bulk carboys (5 L, 10 L, 20 L)
Frequently Asked Questions
How does BZ437 differ from BZ354?
Both are plasma simulants without amino acids and proteins. BZ437 is specified by its osmolality (290–310 mOsm/kg) and pH range (7.35–7.45); Simulated Plasma Fluid (BZ354) is specified at pH 7.4 ± 0.05 and 290 ± 10 mOsm/kg. Order the code your method or earlier orders name.
Does BZ437 contain a preservative?
Yes. The standard product contains an azide-free preservative with bacteriostatic and bactericidal properties. A preservative-free version is available on request.
How long does the solution keep?
Unopened, the stabilized solution has a 1-year shelf life at 2–30 °C. A preservative-free version with a 6-month shelf life and a dried Powder Version Kit with a 2-year shelf life are available on request.
Ordering Information
BZ437 is available in standard laboratory sizes or OEM/bulk supply formats.
📄 MSDS, Technical Datasheet, and Certificate of Analysis (CoA) available upon request
📧 Email: info@biochemazone.com
🌐 Website: www.biochemazone.com
⚠️ For research, education, and in vitro testing only. Not for human or animal use.
