Simulated Synovial Fluid – Sterile Artificial Synovial Fluid for Drug Release and Joint Research, pH 7.4 BZ183
Product Code: BZ183
Manufacturer: Biochemazone
Available Pack Sizes: 100 mL, 200 mL, 500 mL, 1 L
Custom Bulk Quantities Available
Product Overview
Biochemazone Simulated Synovial Fluid BZ183, also called artificial or synthetic synovial fluid, is a sterile solution that simulates the components and pH of synovial fluid, at pH 7.4. It is sterilized by 0.2 µm filtration and can be used directly; the pH can be customized on request.
BZ183 is used for in vitro drug and prodrug release testing of depot injectables intended for joint injection, and for in vitro sustained drug release studies. It has also been used to evaluate the in vitro bioactive behaviour – the in vitro bone-bonding ability – of tissue-engineered osteochondral (bone–cartilage) composites for lesions of the articular cartilage.
It is supplied stabilized and has a 1-year shelf life unopened; a preservative-free version (6-month shelf life) and a dried Powder Version Kit are available on request. The pH and the contents can be customized to the project. This simulated fluid is for scientific research and in vitro use only; it is not for clinical diagnosis or treatment. For the hyaluronic acid version see Artificial Hyaluronic Acid Synovial Fluid (BZ435); for arthritic joints see Synthetic Arthritis Synovial Fluid BZ331.
Key Features & Benefits
✅ Simulates Synovial Fluid – Components and pH of the fluid of the joints
✅ pH 7.4 – Customizable on request
✅ 0.2 µm Sterile-Filtered – Can be used directly
✅ Stabilized – Contains a preservative that stops microbial growth; 1-year shelf life unopened. Preservative-free version on request
✅ Sterile & Ready to Use – No weighing, mixing or pH adjustment before the test
✅ Reproducible & Standardized – Consistent batch-to-batch composition for routine QC and inter-laboratory comparison
✅ Made in Canada – Manufactured under ISO 9001 / GMP quality systems
Applications
💊 Drug Release Testing
• Depot injectables intended for joint injection
• In vitro drug and prodrug release; sustained release studies
🦴 Osteochondral Research
• In vitro bone-bonding ability
• Tissue-engineered osteochondral (bone–cartilage) composites
Typical Properties
- pH: 7.4 (customizable)
- Composition: Formulated to simulate the components of synovial fluid
- Sterility: 0.2 µm filtered
- Format: Sterile, ready-to-use liquid, stabilized
Storage, Shelf Life & Transportation
- Storage Temperature: 2–30 °C, protected from light
- Transportation: At room temperature
- Shelf Life: 1 year (unopened)
- Preservative-Free Version: Available on request – shelf life 6 months unopened at 2–30 °C
- Powder Version Kit: Available on request – 2-year shelf life, easy to reconstitute and suitable for culture-related applications; recommended when a preservative is not required
- After Opening: Handle aseptically; close tightly after use and do not return unused material to the container
Customization Options
Customization available on request:
- pH adjustment to the project requirement
- Contents to your specification
- Preservative-free (not-stabilized) version
- Powder Version Kit, custom pack sizes and bulk carboys (5 L, 10 L, 20 L)
Frequently Asked Questions
What is BZ183 used for?
For in vitro drug and prodrug release testing of depot injectables intended for joint injection, and for in vitro studies of bone-bonding ability and tissue-engineered osteochondral composites.
How long does the solution keep?
Unopened, the stabilized solution has a 1-year shelf life at 2–30 °C. A preservative-free version with a 6-month shelf life and a dried Powder Version Kit with a 2-year shelf life are available on request.
Ordering Information
BZ183 is available in standard laboratory sizes or OEM/bulk supply formats.
📄 MSDS, Technical Datasheet, and Certificate of Analysis (CoA) available upon request
📧 Email: info@biochemazone.com
🌐 Website: www.biochemazone.com
⚠️ For research, education, and in vitro testing only. Not for human or animal use.
