Canine Fed-State Simulated Intestinal Fluid (FeSSIF-Dog) BZ679
Product Code: BZ679
Manufacturer: Biochemazone
Available Pack Sizes: 100 mL, 200 mL, 500 mL, 1000 mL
Custom Bulk Quantities Available
Product Overview
Biochemazone Canine Fed-State Simulated Intestinal Fluid BZ679 is a biorelevant medium for dissolution and solubility testing of drugs under the conditions of the fed dog small intestine. Dogs are the most common species in oral bioavailability and food-effect studies, and their intestinal fluid differs from human fluid, so a canine medium helps link in-vitro results to dog data.
The medium is based on published canine intestinal-fluid data. Compared with the fasted state, it has higher bile-salt and phospholipid levels and lipid digestion products, in a buffer at a pH of about 6.2 (range 5.8–6.5). Dog bile acids are conjugated almost entirely with taurine, so the medium uses taurine-conjugated bile salts, which are animal-derived (from animal bile). The phospholipid is lecithin; its source is stated on the certificate.
Check the composition against the canine data or method you use; we can adjust bile-salt, lipid and pH values. Each batch is prepared with ISO 3696 compliant high-purity water under Biochemazone’s ISO 9001 / GMP quality system.
Key Features & Benefits
✅ Canine Fed State – Based on published dog intestinal data
✅ pH About 6.2 – Range 5.8–6.5
✅ Taurine-Conjugated Bile Salts – As in dog bile
✅ Lipid Digestion Products – Mimics the fed intestine
✅ Pairs With BZ516 – Canine fasted-state medium
✅ Adjustable – Bile-salt, lipid and pH values on request
✅ ISO 3696 Grade Water – Prepared using high-purity laboratory water
✅ Made in Canada – Manufactured under ISO 9001 / GMP quality systems
Applications
💊 Dissolution Testing
• Food-effect prediction in dogs
• Fed vs fasted dissolution comparison
• Solubility of poorly soluble drugs
🐕 Preclinical Development
• Linking in-vitro data to dog PK studies
• Formulation screening for dog studies
🧪 Veterinary Pharma
• Oral veterinary products for dogs
• Palatable chewable formulations
Usage Areas
- Pharma formulation groups
- DMPK and preclinical teams
- Veterinary pharmaceutical companies
- Contract research organisations
- University pharmacy departments
Typical Properties
- Appearance: Slightly turbid, pale-yellow liquid
- pH: about 6.2 (range 5.8–6.5)
- Composition: Buffer salts, taurine-conjugated bile salts (animal-derived), lecithin and lipid digestion products
- Osmolality: Reported for each batch
Storage & Stability
- Storage Temperature: 2–30 °C
- Shelf Life: 1 year for unopened bottles
- Shipping: Room temperature
- Best kept at 2–8 °C for prolonged storage and stability of the bile salt and lecithin components; storage at 2–30 °C is fine for short-term use
- Warm to 37 °C and mix gently before use
Customization Options
- Canine fasted-state medium (see BZ516)
- Canine simulated gastric fluid
- Powder version to make up on site
- Bulk supply for dissolution labs
Ordering Information
BZ679 is available in standard laboratory sizes or OEM/bulk supply formats.
📄 MSDS, Technical Datasheet, and Certificate of Analysis (CoA) available upon request
📧 Email: info@biochemazone.com
🌐 Website: www.biochemazone.com
⚠️ For research and product testing only. Not for veterinary or human therapeutic use.
