Simulated Rat and Mouse Plasma (Surrogate Matrix for Bioanalysis) BZ693
Product Code: BZ693
Manufacturer: Biochemazone
Available Pack Sizes: 50 mL, 100 mL, 200 mL, 500 mL
Custom Bulk Quantities Available
Product Overview
Biochemazone Simulated Rat and Mouse Plasma BZ693 is a surrogate plasma matrix for bioanalysis in the two main preclinical rodent species. Surrogate matrices are used when blank animal plasma is scarce or expensive, for method development, for dilution of study samples, and for measuring compounds that occur naturally in plasma.
The simulant contains albumin, globulins, glucose and electrolytes set from published rat and mouse reference ranges, with a pH of 7.4 ± 0.1, and is supplied with K2EDTA or lithium heparin to match your sample tubes. It is free of drugs and endogenous hormones. It complements our Rodent Serum (BZ525).
The proteins are of bovine (animal) origin and the heparin is porcine; no rodent material is used. If you use it as a surrogate matrix in a regulated method, demonstrate parallelism with authentic plasma as required by ICH M10 and your own SOPs. Each batch is prepared with ISO 3696 compliant high-purity water under Biochemazone’s ISO 9001 / GMP quality system.
Key Features & Benefits
✅ Rat and Mouse – Species-set protein and electrolytes
✅ pH 7.4 ± 0.1 – Physiological
✅ K2EDTA or Heparin – Matches your sample tubes
✅ Analyte-Free – No drugs or endogenous hormones
✅ Available in Volume – Up to 500 mL per bottle
✅ Companion to BZ525 – Matches our rodent serum
✅ ISO 3696 Grade Water – Prepared using high-purity laboratory water
✅ Made in Canada – Manufactured under ISO 9001 / GMP quality systems
Applications
💊 Bioanalysis & DMPK
• LC-MS/MS method development
• Surrogate matrix for endogenous analytes
• Dilution of over-range samples
🐁 Preclinical Studies
• Pharmacokinetic study support
• Plasma protein-binding screening
🔬 Assay Development
• Ligand-binding assay development
• Matrix-effect studies
Usage Areas
- Pharmaceutical DMPK groups
- Contract research organisations
- Bioanalytical laboratories
- Biotech companies
- Academic pharmacology laboratories
Typical Properties
- Appearance: Clear, pale yellow liquid
- pH: 7.4 ± 0.1
- Composition: Bovine albumin and globulins, glucose and electrolytes set to rat or mouse reference ranges; K2EDTA or lithium heparin
- Biological Status: Contains no rodent material; free of drugs and hormones
Storage & Stability
- Storage Temperature: 2–30 °C
- Shelf Life: 1 year for unopened bottles
- Shipping: Room temperature
- Best kept at 2–8 °C for prolonged storage and stability of the albumin and globulin components; storage at 2–30 °C is fine for short-term use
- Mix gently before use; do not shake
Customization Options
- Sodium citrate plasma
- Protein level to your method
- Lipaemic or haemolysed versions
- Frozen aliquots
Ordering Information
BZ693 is available in standard laboratory sizes or OEM/bulk supply formats.
📄 MSDS, Technical Datasheet, and Certificate of Analysis (CoA) available upon request
📧 Email: info@biochemazone.com
🌐 Website: www.biochemazone.com
⚠️ For research and product testing only. Not for veterinary or human therapeutic use.
