Simulated Monkey Plasma, Serum and CSF (Surrogate Matrices) BZ694
Product Code: BZ694
Manufacturer: Biochemazone
Available Pack Sizes: 50 mL, 100 mL, 200 mL, 500 mL
Custom Bulk Quantities Available
Product Overview
Biochemazone Simulated Monkey Plasma, Serum and CSF BZ694 are surrogate matrices for bioanalysis in non-human primate studies. Blank primate matrices are costly and hard to obtain, so a defined simulant is useful for method development, standards and QC preparation, and for work on compounds that occur naturally in the body.
Plasma (K2EDTA) and serum contain albumin, globulins, glucose and electrolytes set from published macaque (cynomolgus and rhesus) reference ranges, with a pH of 7.4 ± 0.1. The CSF is a low-protein artificial cerebrospinal fluid with a pH of about 7.3 (range 7.2–7.4), used where only microlitre volumes of real CSF are available. All three are free of drugs and endogenous hormones.
The proteins are of bovine (animal) origin; no primate material is used. For regulated work, show parallelism with authentic matrix as required by ICH M10 and your own SOPs. It complements our Simulated Monkey Urine (BZ367). Each batch is prepared with ISO 3696 compliant high-purity water under Biochemazone’s ISO 9001 / GMP quality system.
Key Features & Benefits
✅ Three Primate Matrices – Plasma, serum and CSF
✅ pH 7.3–7.4 – Stated for each matrix
✅ Macaque Reference Ranges – Cynomolgus and rhesus data
✅ No Primate Material – Consistent and easy to source
✅ Analyte-Free – No drugs or endogenous hormones
✅ Companion to BZ367 – Matches our monkey urine
✅ ISO 3696 Grade Water – Prepared using high-purity laboratory water
✅ Made in Canada – Manufactured under ISO 9001 / GMP quality systems
Applications
💊 Bioanalysis & DMPK
• LC-MS/MS method development
• Surrogate matrix for endogenous analytes
• Standards and QC preparation
🧠 CNS Drug Development
• CSF method development
• CSF-to-plasma ratio studies
🔬 Assay Development
• Ligand-binding and biomarker assays
• Matrix-effect studies
Usage Areas
- Pharmaceutical DMPK groups
- Contract research organisations
- Bioanalytical laboratories
- Biotech CNS programmes
- Biomarker laboratories
Typical Properties
- Appearance: Plasma and serum clear, pale yellow; CSF clear, colourless
- pH: 7.4 ± 0.1 (plasma, serum); about 7.3 (CSF)
- Composition: Bovine albumin and globulins, glucose and electrolytes in macaque ranges; CSF is low-protein with CSF electrolytes and glucose
- Biological Status: Contains no primate material; free of drugs and hormones
Storage & Stability
- Storage Temperature: 2–30 °C
- Shelf Life: 1 year for unopened bottles
- Shipping: Room temperature
- Best kept at 2–8 °C for prolonged storage and stability of the albumin and globulin components; storage at 2–30 °C is fine for short-term use
- Mix gently before use; do not shake
Customization Options
- Lithium heparin or citrate plasma
- Marmoset or other primate ranges
- Protein-free CSF for LC-MS
- Frozen aliquots
Ordering Information
BZ694 is available in standard laboratory sizes or OEM/bulk supply formats.
📄 MSDS, Technical Datasheet, and Certificate of Analysis (CoA) available upon request
📧 Email: info@biochemazone.com
🌐 Website: www.biochemazone.com
⚠️ For research and product testing only. Not for veterinary or human therapeutic use.
