Monkey Simulated Gastric and Intestinal Fluids (Preclinical Oral Absorption) BZ704
Product Code: BZ704
Manufacturer: Biochemazone
Available Pack Sizes: 100 mL, 200 mL, 500 mL, 1 L
Custom Bulk Quantities Available
Product Overview
Biochemazone Monkey Simulated Gastric and Intestinal Fluids BZ704 are dissolution and solubility media for formulations dosed to non-human primates, such as cynomolgus and rhesus monkeys, in preclinical studies. They help explain differences between monkey and human exposure and choose formulations before an in-vivo study.
The gastric fluid is an acidified salt solution with pepsin and a pH of about 2.0 (range 1.5–3.0). The fasted-state intestinal fluid is a buffered medium with bile salts and phospholipid at a pH of about 6.5 (range 6.0–7.0). Pepsin (porcine) and bile salts are of animal origin.
The compositions are based on published primate GI data, which vary between studies, feeding state and species; we can adjust pH or bile-salt level to match the values you use. Each batch is prepared with ISO 3696 compliant high-purity water under Biochemazone’s ISO 9001 / GMP quality system.
Key Features & Benefits
✅ Primate-Specific Media – Gastric and fasted intestinal
✅ Gastric pH About 2.0 – Intestinal pH about 6.5
✅ Pepsin in Gastric Fluid – Porcine origin
✅ Bile Salts and Phospholipid – For poorly soluble actives
✅ Adjustable – Matched to your data
✅ Consistent Batch-to-Batch – Repeatable screening
✅ ISO 3696 Grade Water – Prepared using high-purity laboratory water
✅ Made in Canada – Manufactured under ISO 9001 / GMP quality systems
Applications
🐒 Preclinical Formulation
• Formulation choice before primate studies
• Dissolution of capsules and tablets
• Supersaturation and precipitation tests
💊 DMPK Support
• Solubility input for PBPK models
• Monkey-to-human translation
🔬 Research
• Species differences in oral absorption
• Drug stability in gastric conditions
Usage Areas
- Pharma formulation groups
- DMPK groups
- Preclinical CROs
- Biopharmaceutics researchers
- Universities
Typical Properties
- Appearance: Clear, colourless liquid (gastric); slightly hazy (intestinal)
- pH: gastric about 2.0 (range 1.5–3.0); intestinal about 6.5 (range 6.0–7.0)
- Composition: Acidified salts with pepsin (porcine); buffer with bile salts and phospholipid
- Water Grade: ISO 3696 purified water
Storage & Stability
- Storage Temperature: 2–30 °C
- Shelf Life: 1 year for unopened bottles
- Shipping: Room temperature
- Best kept at 2–8 °C for prolonged storage and stability of the pepsin, bile salt and phospholipid components; storage at 2–30 °C is fine for short-term use
- Warm to 37 °C before use
Customization Options
- Fed-state intestinal fluid
- Enzyme-free gastric fluid
- pH and bile-salt levels from your data
- Dry powder versions
Ordering Information
BZ704 is available in standard laboratory sizes or OEM/bulk supply formats.
📄 MSDS, Technical Datasheet, and Certificate of Analysis (CoA) available upon request
📧 Email: info@biochemazone.com
🌐 Website: www.biochemazone.com
⚠️ For research and product testing only. Not for veterinary or human therapeutic use.
