Rat Fed State Simulated Gastric Fluid – pH 4.5 (Postprandial Gastric Medium) BZ547
Product Code: BZ547
Manufacturer: Biochemazone
Available Pack Sizes: 100 mL, 200 mL, 500 mL, 1 L
Custom Bulk Quantities Available
Product Overview
Biochemazone Rat Fed State Simulated Gastric Fluid BZ547 is a laboratory-formulated synthetic gastric medium designed to reproduce the physiological conditions of the rat stomach after food intake (fed state). Unlike fasted gastric environments, the fed gastric state exhibits a higher pH, increased buffering capacity, elevated nutrient content, and altered ionic composition, all of which can significantly influence drug dissolution, stability, and gastrointestinal behavior.
This formulation is prepared using ISO 3696 compliant high-purity water to ensure high reproducibility and analytical consistency in pharmaceutical and preclinical research applications. The medium is engineered to mimic the complex postprandial gastric environment encountered in rats following feeding conditions.
BZ547 is particularly useful for evaluating the effects of food on drug release, solubility, formulation stability, gastric residence behavior, and bioavailability under fed gastric conditions. The formulation may contain physiologically relevant buffering components and nutrient-mimicking constituents to better simulate gastric conditions after feeding.
Key Features & Benefits
✅ pH 4.5 (Fed Gastric Condition) – Simulates postprandial gastric acidity in rats
✅ Fed State Gastric Simulation – Mimics elevated gastric buffering conditions after feeding
✅ ISO 3696 Grade Water – Prepared using high-purity laboratory water standards
✅ Physiologically Relevant Composition – Designed to reflect fed gastric electrolyte balance
✅ Enhanced Buffering Capacity – Represents gastric conditions influenced by food intake
✅ Freshly Prepared Formulation – Ensures stability and consistency in testing
✅ Reproducible & Standardized – Reliable for comparative pharmaceutical studies
✅ Ready-to-Use Solution – Suitable for direct laboratory application
Applications
🧪 Pharmaceutical Dissolution Testing
• Drug dissolution studies under fed gastric conditions
• Food-effect evaluation on oral formulations
• Modified-release dosage form testing
🐀 Preclinical Gastrointestinal Studies
• Rat fed-state gastric simulation
• Bioavailability and absorption modeling
• Gastric retention and transit evaluation
🔬 Formulation Development
• Stability testing in postprandial gastric environments
• Solubility analysis under elevated gastric pH
• Evaluation of food-dependent drug release profiles
🧬 Biopharmaceutical Research
• Fed vs fasted comparative studies
• Gastric interaction analysis of oral drug products
• Enteric and protective coating performance assessment
Typical Properties
- Appearance: Slightly opalescent to clear solution
• pH: 4.5 (Fed gastric physiological condition)
• Water Grade: ISO 3696 purified water
• Ionic Composition: Fed-state gastric electrolyte profile
• Buffering Capacity: Elevated compared to fasted gastric media
• Viscosity: Low to moderate (customizable upon request)
• Composition: Buffered gastric simulation medium with nutrient-mimicking components
Storage & Stability
- Storage Temperature: 2–8 °C recommended
• Shelf Life: 6 to 12 months (sealed container)
• Shipping: Stable at room temperature
Customization Options
- pH adjustment for alternative fed-state gastric conditions
• Nutrient composition modification
• Buffer strength adjustment
• Enzyme supplementation options (pepsin inclusion available upon request)
• Species-specific gastric simulation customization
Ordering Information
BZ547 is available in standard laboratory sizes or OEM/bulk supply formats.
📄 MSDS, Technical Datasheet, and Certificate of Analysis (CoA) available upon request
📧 Email: info@biochemazone.com
🌐 Website: www.biochemazone.com
⚠️ For research, education, and in vitro testing only. Not for human or animal use.
