Human Oral Fluid Substitute – Synthetic Oral Fluid with Mucin, Amylase and Lysozyme, pH 6.8 BZ494
Product Code: BZ494
Manufacturer: Biochemazone
Available Pack Sizes: 100 mL, 200 mL, 500 mL, 1 L
Custom Bulk Quantities Available
Product Overview
Biochemazone Human Oral Fluid Substitute BZ494 is a ready-to-use, sterile synthetic alternative to natural human saliva at pH 6.8. It mimics the biochemical composition, viscosity and physiological properties of real oral fluid, with the inorganic and organic constituents found in saliva: the electrolytes sodium, potassium, calcium, chloride, bicarbonate and phosphate, together with mucin, urea, amylase, lysozyme and proteins.
BZ494 is used in biomedical research on salivary diagnostics, drug metabolism and oral health; to evaluate oral hygiene products such as toothpaste, mouthwash and dental coatings; for drug dissolution studies and in vitro saliva–drug interaction work; in forensic toxicology and biomarker research; and to test the compatibility of saliva-exposed materials such as food packaging, medical devices and prosthetics.
BZ494 contains a preservative to maintain sterility and stability, so it is supplied stabilized, with a 1-year shelf life unopened; a preservative-free version is available on request. Because it contains proteins and enzymes, keep it at 2–8 °C if it is to be stored for a long time. For a simpler synthetic matrix see Artificial Human Saliva BZ323; for assay development see Simulated Saliva for Lateral Flow Assays BZ500.
Key Features & Benefits
✅ Accurate Biomimicry – Electrolytes, mucin, urea, amylase, lysozyme and proteins of natural saliva
✅ pH 6.8 – Within the physiological range of 6.2 to 7.6; customizable
✅ Stabilized – Preservative added to stop microbial growth; 1-year shelf life unopened
✅ Sterile & Ready to Use – No weighing, mixing or pH adjustment before the test
✅ Reproducible & Standardized – Consistent batch-to-batch composition for routine QC and inter-laboratory comparison
✅ Made in Canada – Manufactured under ISO 9001 / GMP quality systems
Applications
🧪 Biomedical Research
• Salivary diagnostics
• Drug metabolism studies
• Oral health research
🪥 Dental & Oral Care Testing
• Toothpaste and mouthwash evaluation
• Dental coatings and materials
• Saliva substitutes
💊 Pharmaceutical Applications
• Drug dissolution studies
• Saliva–drug interaction assessment
• Oral dosage form development
🔬 Forensics & Materials
• Forensic toxicology and biomarker analysis
• Food packaging and medical devices
• Prosthetics and saliva-exposed surfaces
Typical Properties
- Appearance: Slightly viscous solution
- pH: 6.8 (physiological range 6.2 to 7.6; customizable)
- Electrolytes: Sodium, potassium, calcium, chloride, bicarbonate and phosphate
- Organic components: Mucin, urea, amylase, lysozyme and proteins
- Preservative: Added to maintain sterility and stability
- Format: Sterile, ready-to-use liquid, stabilized
Storage, Shelf Life & Transportation
- Storage Temperature: 2–30 °C, protected from light
- Transportation: At room temperature
- Shelf Life: 1 year (unopened)
- Preservative-Free Version: Available on request – shelf life 6 months unopened at 2–30 °C
- Protein- and Enzyme-Containing Product: Best kept at 2–8 °C for prolonged storage and activity; storage at 2–30 °C is fine for short-term use
- Powder Version Kit: Available on request – 2-year shelf life, easy to reconstitute and suitable for culture-related applications; recommended when a preservative is not required
- After Opening: Handle aseptically; close tightly after use and do not return unused material to the container
Customization Options
Customization available on request:
- pH adjustment to the project requirement
- Tailored composition for your research or industrial requirement
- Preservative-free version
- Powder Version Kit, custom pack sizes and bulk carboys (5 L, 10 L, 20 L)
Frequently Asked Questions
How does BZ494 differ from a simple artificial saliva?
Besides the salts, it contains the organic constituents of saliva – mucin, urea, amylase, lysozyme and proteins – so it reproduces the viscosity, enzyme activity and protein content of oral fluid.
How should BZ494 be stored?
Store it at 2–30 °C; for prolonged storage and to keep the enzymes active, 2–8 °C is best. It is shipped at room temperature. Unopened, the stabilized solution has a 1-year shelf life.
Ordering Information
BZ494 is available in standard laboratory sizes or OEM/bulk supply formats.
📄 MSDS, Technical Datasheet, and Certificate of Analysis (CoA) available upon request
📧 Email: info@biochemazone.com
🌐 Website: www.biochemazone.com
⚠️ For research, education, and in vitro testing only. Not for human or animal use.
