Simulated Endosteal Fluid – Synthetic Bone Marrow Fluid for Bone Research, pH 7.4 BZ440
Product Code: BZ440
Manufacturer: Biochemazone
Available Pack Sizes: 100 mL, 200 mL, 500 mL, 1 L
Custom Bulk Quantities Available
Product Overview
Biochemazone Simulated Endosteal Fluid BZ440, also called artificial endosteal fluid, is a ready-to-use synthetic solution designed to replicate the properties of natural endosteal fluid, at pH 7.4. Endosteal fluid is found within the bone marrow and lines the inner surfaces of bones. It contains water, electrolytes, proteins and enzymes, which mimic the physical and chemical characteristics of the natural fluid. The pH of natural endosteal fluid is typically around 7.4, and the standard formulation is set at 7.4. Its viscosity and density are matched to the natural fluid, and it stays stable through the test.
Research laboratories use it to study bone function, pathology and metabolic processes within the bone marrow and the endosteal space, and in tests that assess biomarkers and simulate conditions within the endosteal region. It is also used to test and calibrate medical devices and diagnostic tools that interact with bone fluids, such as bone marrow sensors and imaging systems, in research on bone metabolism, bone marrow function and the effects of treatments on bone, and in training, without the need for natural endosteal fluid.
It is supplied stabilized and has a 1-year shelf life unopened; a preservative-free version (6-month shelf life) and a dried Powder Version Kit are available on request. Because it contains proteins and enzymes, keep it at 2–8 °C if it is to be stored for a long time. The formulation, minerals, organic content and pH can be customized. This simulated fluid is for scientific research and in vitro use only; it is not for clinical diagnosis or treatment. For the liver see Simulated Periportal Fluid (BZ439); for the general interstitial fluid see Simulated Interstitial Fluid (BZ254).
Key Features & Benefits
✅ Replicates Natural endosteal fluid – Water, electrolytes, proteins and enzymes
✅ pH 7.4 – As natural endosteal fluid; customizable
✅ Matched Properties – Viscosity, density and pH close to the natural fluid
✅ Stabilized – Contains a preservative that stops microbial growth; 1-year shelf life unopened. Preservative-free version on request
✅ Ready to Use – No weighing, mixing or pH adjustment before the test
✅ Reproducible & Standardized – Consistent batch-to-batch composition for routine QC and inter-laboratory comparison
✅ Made in Canada – Manufactured under ISO 9001 / GMP quality systems
Applications
🦴 Bone Research
• Bone function, pathology and metabolic processes
• Biomarker assessment in the endosteal region
🩺 Device Testing & Calibration
• Bone marrow sensors and imaging systems
• Devices that monitor bone health or detect bone-related biomarkers
🎓 Research, Training & Education
• Bone metabolism and bone marrow function research
• Hands-on training without natural endosteal fluid
Typical Properties
- pH: 7.4 (customizable)
- Composition: Water, electrolytes, proteins and enzymes
- Viscosity and density: Matched to the natural fluid
- Format: Ready-to-use liquid, stabilized
Storage, Shelf Life & Transportation
- Storage Temperature: 2–30 °C, protected from light
- Transportation: At room temperature
- Shelf Life: 1 year (unopened)
- Preservative-Free Version: Available on request – shelf life 6 months unopened at 2–30 °C
- Protein- and Enzyme-Containing Product: Best kept at 2–8 °C for prolonged storage and activity; storage at 2–30 °C is fine for short-term use
- Powder Version Kit: Available on request – 2-year shelf life, easy to reconstitute and suitable for culture-related applications; recommended when a preservative is not required
- After Opening: Handle aseptically; close tightly after use and do not return unused material to the container
Customization Options
Customization available on request:
- pH adjustment to the project requirement
- Formulation, minerals and organic content
- Preservative-free (not-stabilized) version
- Powder Version Kit, custom pack sizes and bulk carboys (5 L, 10 L, 20 L)
Frequently Asked Questions
What does BZ440 contain?
Water, electrolytes, proteins and enzymes, at pH 7.4, with a viscosity and density matched to natural endosteal fluid.
How should it be stored?
Store it at 2–30 °C; because it contains proteins and enzymes, 2–8 °C is best for prolonged storage and activity. It is shipped at room temperature. Unopened, the stabilized solution has a 1-year shelf life; a preservative-free version with a 6-month shelf life and a dried Powder Version Kit with a 2-year shelf life are available on request.
Ordering Information
BZ440 is available in standard laboratory sizes or OEM/bulk supply formats.
📄 MSDS, Technical Datasheet, and Certificate of Analysis (CoA) available upon request
📧 Email: info@biochemazone.com
🌐 Website: www.biochemazone.com
⚠️ For research, education, and in vitro testing only. Not for human or animal use.
