Simulated Rectal Fluid (Suppository and Enema Release Testing) BZ651
Product Code: BZ651
Manufacturer: Biochemazone
Available Pack Sizes: 100 mL, 200 mL, 500 mL, 1 L
Custom Bulk Quantities Available
Product Overview
Biochemazone Simulated Rectal Fluid BZ651 is a release medium for suppositories, rectal gels, enemas and rectal microbicides. The rectum holds only a few millilitres of fluid with a near-neutral pH and a weak buffer, so ordinary dissolution media can give misleading release and melting results.
Two types are offered. The buffered electrolyte fluid is a low-capacity phosphate buffer with sodium and potassium chloride at a pH of about 7.4 (range 7.2–7.6). The mucin type adds porcine gastric mucin (animal-derived) to reproduce the mucus layer that affects spreading and adhesion of rectal products.
Rectal fluid composition is not standardised; check the pH, buffer and volume against your method, and we can adjust them. Each batch is prepared with ISO 3696 compliant high-purity water under Biochemazone’s ISO 9001 / GMP quality system.
Key Features & Benefits
✅ Near-Neutral pH – About 7.4 (range 7.2–7.6)
✅ Low Buffer Capacity – Like the real rectal environment
✅ Two Types – Electrolyte fluid or with mucin
✅ Suppository Testing – Melting, spreading and release
✅ Small and Large Packs – 100 mL to 1 L
✅ Consistent Batch-to-Batch – Repeatable release data
✅ ISO 3696 Grade Water – Prepared using high-purity laboratory water
✅ Made in Canada – Manufactured under ISO 9001 / GMP quality systems
Applications
💊 Rectal Dosage Forms
• Suppository release and melting tests
• Rectal gel and foam spreading
• Enema compatibility
🦠 Microbicide Research
• Rectal microbicide gel testing
• Mucoadhesion studies (mucin type)
🧪 Formulation Development
• Excipient and base selection
• Stability of released drug
Usage Areas
- Pharmaceutical formulation laboratories
- Suppository manufacturers
- Microbicide research groups
- Contract research organisations
- Universities
Typical Properties
- Appearance: Clear liquid; slightly opalescent with mucin
- pH: about 7.4 (range 7.2–7.6)
- Composition: Low-capacity phosphate buffer with sodium and potassium chloride; porcine gastric mucin in the mucin type
- Water Grade: ISO 3696 purified water
Storage & Stability
- Storage Temperature: 2–30 °C
- Shelf Life: 1 year for unopened bottles
- Shipping: Room temperature
- Warm to 37 °C before testing
Customization Options
- Other pH values and buffer strengths
- Higher mucin levels
- Diseased-state (inflamed) rectal fluid
- Powder versions
Ordering Information
BZ651 is available in standard laboratory sizes or OEM/bulk supply formats.
📄 MSDS, Technical Datasheet, and Certificate of Analysis (CoA) available upon request
📧 Email: info@biochemazone.com
🌐 Website: www.biochemazone.com
⚠️ For research and product testing only. Contains animal-derived mucin (mucin type). Not for veterinary or human therapeutic use.
