Dialyzer Clearance Test Solution and Uraemic Plasma Simulant (ISO 8637-1) BZ646
Product Code: BZ646
Manufacturer: Biochemazone
Available Pack Sizes: 1 L, 5 L, 10 L
Custom Bulk Quantities Available
Product Overview
Biochemazone Dialyzer Clearance Test Solution BZ646 is a ready-made test fluid for measuring how well haemodialyzers and haemofilters remove waste solutes. Clearance testing of dialyzers is described in ISO 8637-1, which uses aqueous test solutions of marker solutes.
Two solutions are offered. The clearance test solution contains urea, creatinine and phosphate as small solutes and vitamin B12 as a larger marker, in a physiological salt base. The uraemic plasma simulant adds albumin for studies of protein effects and albumin loss. Both have a pH of 7.4 ± 0.2, and the concentration of each marker is reported on the certificate.
Check the markers and concentrations required by your edition of ISO 8637-1 or your internal method. It complements our Artificial Dialysis Waste Fluid (BZ512). Each batch is prepared with ISO 3696 compliant high-purity water under Biochemazone’s ISO 9001 / GMP quality system. The albumin is of bovine origin.
Key Features & Benefits
✅ Marker-Solute Solution – Urea, creatinine, phosphate, vitamin B12
✅ Uraemic Plasma Simulant – With albumin
✅ pH 7.4 ± 0.2 – Physiological
✅ Measured Concentrations – Reported on each certificate
✅ Large Volumes – Up to 10 L for flow-loop tests
✅ Consistent Batch-to-Batch – Comparable clearance data
✅ ISO 3696 Grade Water – Prepared using high-purity laboratory water
✅ Made in Canada – Manufactured under ISO 9001 / GMP quality systems
Applications
🩺 Dialyzer Testing
• Clearance measurement to ISO 8637-1
• Haemofilter and haemodiafilter performance
• Batch release and design verification
🔬 Sensor & Device R&D
• Urea and creatinine sensors for dialysis
• Wearable and portable kidney devices
• Sorbent-cartridge testing
📋 Research
• Uraemic-toxin removal studies
• Membrane development
Usage Areas
- Dialyzer and haemofilter manufacturers
- Dialysis machine and sensor developers
- Device test laboratories
- Nephrology research groups
- Universities
Typical Properties
- Appearance: Clear, pink-red liquid (vitamin B12); slightly opalescent with albumin
- pH: 7.4 ± 0.2
- Composition: Urea, creatinine, phosphate and vitamin B12 in a physiological salt base; albumin added in the plasma simulant
- Water Grade: ISO 3696 purified water
Storage & Stability
- Storage Temperature: 2–30 °C
- Shelf Life: 1 year for unopened bottles
- Shipping: Room temperature
- Best kept at 2–8 °C for prolonged storage and stability of the albumin (plasma simulant) components; storage at 2–30 °C is fine for short-term use
- Warm to 37 °C before testing
Customization Options
- Marker concentrations matched to your method
- Middle-molecule markers
- Protein-bound uraemic toxins
- Bulk supply
Ordering Information
BZ646 is available in standard laboratory sizes or OEM/bulk supply formats.
📄 MSDS, Technical Datasheet, and Certificate of Analysis (CoA) available upon request
📧 Email: info@biochemazone.com
🌐 Website: www.biochemazone.com
⚠️ For laboratory testing only. Not for human or animal use.
