Canine FaSSGF and FaSSIF (Fasted-State Biorelevant Media for Dogs) BZ667
Product Code: BZ667
Manufacturer: Biochemazone
Available Pack Sizes: Powder kits that make 1 L, 5 L or 10 L
Custom Bulk Quantities Available
Product Overview
Biochemazone Canine FaSSGF and FaSSIF BZ667 are fasted-state biorelevant media that simulate the stomach and small-intestinal fluids of the dog. They are based on the canine media described by Arndt et al. (2013, European Journal of Pharmaceutics and Biopharmaceutics) and are used to predict how drugs dissolve in beagle studies and to develop veterinary tablets and chews.
Canine FaSSGF is an acidic gastric medium with a pH of about 1.5 and a low level of bile salt and phospholipid. Canine FaSSIF reflects the higher bile-salt content and more alkaline pH of the fasted dog intestine, with a pH of about 7.5. The bile salts are animal-derived, and the phospholipid is lecithin.
Each kit contains pre-weighed buffer salts and a bile-salt/phospholipid powder, with instructions for making the medium in purified water. Check the compositions against the original paper and your study protocol. Made under Biochemazone’s ISO 9001 / GMP quality system.
Key Features & Benefits
✅ Dog-Specific Media – Based on Arndt et al. (2013)
✅ Fasted Gastric and Intestinal – FaSSGF and FaSSIF, or both as a set
✅ Stated pH – FaSSGF about 1.5; FaSSIF about 7.5
✅ Bile Salts and Lecithin – Mixed micelles like fasted dog fluids
✅ Powder Kits – Make 1 L to 10 L fresh
✅ 24-Month Shelf Life – Stored dry
✅ Batch Certificate – Lot and preparation data recorded
✅ Made in Canada – Manufactured under ISO 9001 / GMP quality systems
Applications
🐕 Veterinary Formulation
• Dissolution of tablets and chewable treats for dogs
• Palatable dosage-form development
• Generic veterinary product comparison
💊 Pre-Clinical Pharma
• Predicting oral absorption in beagle studies
• Dog-to-human translation of dissolution data
• Solubility screening of new compounds
🔬 Research
• Species differences in drug solubility
• Teaching in biopharmaceutics
Usage Areas
- Pharmaceutical formulation groups
- DMPK and pre-clinical teams
- Animal-health R&D companies
- Contract dissolution laboratories
- Universities
Typical Properties
- Appearance: White to off-white powders; slightly cloudy medium when prepared
- pH (prepared): FaSSGF about 1.5; FaSSIF about 7.5
- Composition: Buffer salts and sodium chloride with bile salt (animal-derived) and lecithin, according to the medium
- Preparation: Dissolve in ISO 3696 Grade 3 or better water; equilibrate before use
Storage & Stability
- Storage Temperature: 2–30 °C
- Shelf Life: 2 years unopened (dry powder)
- Shipping: Room temperature
- Best kept at 2–8 °C for prolonged storage and stability of the bile salt and lecithin components; storage at 2–30 °C is fine for short-term use
- Prepared medium: use within 48 hours
Customization Options
- Canine FeSSIF (fed state)
- Ready-to-use liquid media
- Custom bile-salt levels
- Bulk kits for dissolution laboratories
Ordering Information
BZ667 is available in standard laboratory sizes or OEM/bulk supply formats.
📄 MSDS, Technical Datasheet, and Certificate of Analysis (CoA) available upon request
📧 Email: info@biochemazone.com
🌐 Website: www.biochemazone.com
⚠️ For research and product testing only. Not for veterinary or human therapeutic use.
