Hyperosmolar Dry Eye Tear Simulant (300 to 360 mOsm/L) BZ653
Product Code: BZ653
Manufacturer: Biochemazone
Available Pack Sizes: 50 mL, 100 mL, 200 mL
Custom Bulk Quantities Available
Product Overview
Biochemazone Hyperosmolar Dry Eye Tear Simulant BZ653 is a series of artificial tears at raised osmolarity. Tear hyperosmolarity is a core feature of dry eye disease, and a graded series lets developers test tear-osmolarity sensors and study how eye drops and contact lenses behave in a dry-eye tear film.
Four levels are offered: 300 mOsm/L as a normal control and 320, 340 and 360 mOsm/L representing increasingly severe dry eye. Each is a tear-electrolyte solution (sodium, potassium, calcium, magnesium, chloride and bicarbonate) at a pH of about 7.4 (range 7.2–7.6), with the osmolarity raised mainly by sodium chloride. The measured osmolality of each batch is recorded on the certificate.
Published cut-offs for dry eye vary between studies and devices; choose levels to suit your study, and we can make any value in between. The simulant is protein-free; lysozyme, lactoferrin or mucin can be added on request. Each batch is prepared with ISO 3696 compliant high-purity water under Biochemazone’s ISO 9001 / GMP quality system.
Key Features & Benefits
✅ Graded Osmolarity Series – 300, 320, 340 and 360 mOsm/L
✅ pH About 7.4 – Range 7.2–7.6
✅ Osmolality Recorded – On each batch certificate
✅ Tear Electrolytes – Na, K, Ca, Mg, Cl, bicarbonate
✅ Protein-Free Base – Proteins added on request
✅ Single Levels or Sets – Buy one or all four
✅ ISO 3696 Grade Water – Prepared using high-purity laboratory water
✅ Made in Canada – Manufactured under ISO 9001 / GMP quality systems
Applications
👁️ Dry-Eye Product R&D
• Testing lubricating and hypotonic eye drops
• Contact-lens behaviour in dry-eye tears
• Ocular-surface cell model media
📟 Tear-Osmolarity Sensors
• Sensor calibration and linearity checks
• Point-of-care device verification
🔬 Research
• Tear-film evaporation models
• Teaching in ocular physiology
Usage Areas
- Ophthalmic research laboratories
- Eye-drop and contact-lens manufacturers
- Diagnostic device developers
- Contract test laboratories
- Universities
Typical Properties
- Appearance: Clear, colourless liquid
- pH: about 7.4 (range 7.2–7.6)
- Osmolarity: 300, 320, 340 or 360 mOsm/L
- Composition: Tear electrolytes with added sodium chloride; protein-free
- Water Grade: ISO 3696 purified water
Storage & Stability
- Storage Temperature: 2–30 °C
- Shelf Life: 1 year for unopened bottles
- Shipping: Room temperature
- Keep tightly closed to prevent evaporation
Customization Options
- Any osmolarity from 280 to 400 mOsm/L
- Added lysozyme, lactoferrin or mucin
- Single-use vials for sensor testing
- Bulk supply
Ordering Information
BZ653 is available in standard laboratory sizes or OEM/bulk supply formats.
📄 MSDS, Technical Datasheet, and Certificate of Analysis (CoA) available upon request
📧 Email: info@biochemazone.com
🌐 Website: www.biochemazone.com
⚠️ For laboratory research only. Not for use in the eye. Not for human or animal use.
