Elevated-pH Gastric Fluid, pH 4 to 6 (Hypochlorhydric Stomach Dissolution) BZ650
Product Code: BZ650
Manufacturer: Biochemazone
Available Pack Sizes: 1 L, 5 L, 10 L
Custom Bulk Quantities Available
Product Overview
Biochemazone Elevated-pH Gastric Fluid BZ650 simulates a stomach with little acid, as seen in patients taking proton-pump inhibitors or H2 blockers, in many elderly people and after some gastric surgery. Weakly basic drugs and pH-dependent formulations can dissolve very differently at these higher pH values than in standard 0.1 M HCl or FaSSGF.
Three fluids are offered, at pH 4.0, 5.0 and 6.0, each in a low-capacity buffer with sodium chloride at a physiological level so that the pH holds during dissolution without being unrealistically strong. The fluids are enzyme-free; pepsin has little activity at these pH values and can be added on request.
Choose the pH that matches the clinical situation you are modelling, and check the buffer against your dissolution method. We can supply other pH values or add bile salt and lecithin to match FaSSGF. Each batch is prepared with ISO 3696 compliant high-purity water under Biochemazone’s ISO 9001 / GMP quality system.
Key Features & Benefits
✅ pH 4.0, 5.0 and 6.0 – Set and checked for each fluid
✅ Acid-Suppressed Stomach – PPI, H2 blocker and elderly models
✅ Low-Capacity Buffer – Holds pH without over-buffering
✅ Enzyme-Free – Pepsin available on request
✅ Single pH or Sets – Buy one or all three
✅ Up to 10 L – For USP apparatus 1 and 2 vessels
✅ ISO 3696 Grade Water – Prepared using high-purity laboratory water
✅ Made in Canada – Manufactured under ISO 9001 / GMP quality systems
Applications
💊 Dissolution Testing
• Weakly basic drugs under acid suppression
• pH-dependent release screening
• Drug-drug interaction risk with acid reducers
👵 Special Populations
• Elderly and hypochlorhydric patients
• Post-gastric-surgery models
🧪 Formulation Development
• Salt and form selection
• Enteric-coat robustness checks
Usage Areas
- Pharmaceutical formulation laboratories
- Dissolution and QC laboratories
- Contract research organisations
- Generic-drug developers
- Universities
Typical Properties
- Appearance: Clear, colourless liquid
- pH: 4.0, 5.0 or 6.0 (± 0.1)
- Composition: Low-capacity buffer with sodium chloride; enzyme-free
- Water Grade: ISO 3696 purified water
Storage & Stability
- Storage Temperature: 2–30 °C
- Shelf Life: 1 year for unopened bottles
- Shipping: Room temperature
- Warm to 37 °C before testing
Customization Options
- Other pH values between 3 and 7
- Added pepsin
- Bile salt and lecithin as in FaSSGF
- Powder versions
Ordering Information
BZ650 is available in standard laboratory sizes or OEM/bulk supply formats.
📄 MSDS, Technical Datasheet, and Certificate of Analysis (CoA) available upon request
📧 Email: info@biochemazone.com
🌐 Website: www.biochemazone.com
⚠️ For laboratory testing only. Not for human or animal use.
