Simulated Body Fluid (SBF) ISO 23317 Method

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Simulated Body Fluid (SBF) ISO 23317 Method

Simulated Body Fluid (SBF) is a metastable solution, a supersaturated solution of apatite containing calcium ions and phosphate ions. It is widely used in the evaluation of bioactive materials in vitro and can form bone-like apatite. This reagent is only used in the field of scientific research.

SBF Pack Size: 100 mL, 200 mL, 500 mL, 1000 mL

Validity: 6 months

Transportation and storage: transportation at room temperature, storage at 2-8 ℃.

Note:

1. Simulated Body Fluid is a sterile solution and can be used directly.
2. Simulated Body Fluid, stored at 4 degrees, transported at room temperature.
3. This product is limited to the scientific research of professionals, cannot be used for clinical diagnosis or treatment, and cannot be used for food or medicine, and cannot be stored in ordinary houses.
4. For your safety and health, please wear a lab coat and disposable gloves.

Ion concentrations (mM) of SBF and human blood plasma

Ion Simulate Body Fluid Blood plasma
Na+ 142.0 142.0
K+ 5.0 5.0
Mg2+ 1.5 1.5
Ca2+ 2.5 2.5
Cl 148.8 103.0
HCO3 4.2 27.0
HPO42- 1.0 1.0
SO42- 0.5 0.5

Simulated Body Fluid (SBF) ISO 23317 Method

Biochemazone™ Simulated Body Fluid (SBF) ISO 23317 Method – BZ361

Biochemazone™’s Simulated Body Fluid (SBF) BZ361 is meticulously formulated in accordance with ISO 23317:2014 standards. This internationally recognized method evaluates the formation of apatite layers on implant surfaces, ensuring materials are bioactive and suitable for direct bone integration. Specifically developed for testing the biocompatibility of surgical implants, this solution replicates the ionic composition of human plasma to mimic physiological conditions.

When bioactive materials come into contact with SBF, a calcium- and phosphorus-rich apatite layer forms, replicating the natural process of bone mineralization. This layer allows implants to bond seamlessly with living bone tissue, making the solution indispensable for assessing the effectiveness of implant materials in orthopedic, dental, and other surgical applications.

Key Features:

  • ISO-Compliant Formulation: Prepared to meet the requirements of ISO 23317:2014, ensuring reliability and precision in apatite layer testing.
  • Human Plasma Analog: Matches the ionic composition of blood plasma, providing a highly accurate simulation of in vivo conditions.
  • Apatite-Forming Evaluation: Ideal for assessing bioactivity and the bonding potential of implant surfaces.
  • Versatile Applications: Beyond implant testing, SBF can be used to study drug release profiles for injectable formulations, implantable drug delivery systems, and more.

Applications:

  • Testing surgical implant surfaces for bioactivity and bone integration potential.
  • Evaluating the release rates of drugs from intramuscular, subcutaneous, and intravenous delivery systems.
  • Research and development of new biomaterials and pharmaceutical formulations.

Biochemazone™’s SBF BZ361 provides a reliable and consistent solution for researchers and manufacturers focused on advancing biomaterial science and implant technology.

Additional information

mL

1000mL, 100mL, 200mL, 500mL